Shire Human Genetic Therapies — 213 certified H-1B filings (FY2016–FY2026)

6
Filings · FY2025
$128k
Median base · FY2025
Downstream Development Engineer II
Top role · 6 all-time
MA
Top state · 211 all-time
FY

Shire Human Genetic Therapies filed 6 certified H-1B LCAs in FY2025 (down 62% from the year before), with a median base salary of $128k and the middle 50% of offers between $110k and $161k. That is 4% below the market median for the same job titles. Across all years it has 213 certified filings since FY2016, most often for Downstream Development Engineer II in Massachusetts.

How much does Shire Human Genetic Therapies pay H-1B workers?

Certified base salary by fiscal year: each box is the p25–p75 range, the heavy line the median, the whiskers reach p10–p90. $128k median in FY2025. Base pay only — hover a year for its figures.

$50k$100k$150k$200k$250k’16’17’18’19’20’21’22’23’24’25’26

How has Shire Human Genetic Therapies's H-1B hiring changed by year?

18 certified filings in FY2016 → 6 in FY2026. The change column is each year against the one before.

Shire Human Genetic Therapies certified H-1B filings and base salary by fiscal year
Fiscal yearFilingsvs prior FYMedian base
FY202660%$133k
FY20256−62%$128k
FY202416+220%$130k
FY20235−44%$154k
FY20229−64%$125k
FY202125−4%$117k
FY202026−10%$110k
FY201929−38%$100k
FY201847+81%$110k
FY201726+44%$84k
FY201618—$90k

Which wage levels does Shire Human Genetic Therapies file?

DOL prevailing-wage levels I–IV approximate experience tiers (I = entry, IV = fully competent). 56% of Shire Human Genetic Therapies's filings sit at Level III–IV. A heavy I–II skew reads as entry-level or contractor-style hiring; a heavy IV skew as senior in-house roles — and higher levels earn more lottery entries.

Share of 189 filings with a wage level · all years

16%
29%
19%
37%
  • Level I15.9%30
  • Level II28.6%54
  • Level III18.5%35
  • Level IV37.0%70

What jobs does Shire Human Genetic Therapies sponsor for H-1B?

The most-filed job titles across all years (DOL titles, employer pay-grade codes stripped), with base-salary percentiles.

Shire Human Genetic Therapies most-sponsored H-1B job titles with base-salary percentiles
Job titleFilingsMedian base
Downstream Development Engineer II6$82k
QC Analyst II6$72k
Senior Validation Engineer4$105k
Development Specialist II4$68k
Sr. Downstream Development Engineer3$100k
Scientist3$103k
Dmpk Lead3$107k
Senior QC Analyst3$110k
Senior Engineer3$94k
Lead, Regulatory Affairs Device, Plasma-Derived Therapies Bu2$192k

Where does Shire Human Genetic Therapies hire H-1B workers?

Worksite states on the certified filings, all years. Deeper pink = more filings; hover a state for its figures.

2211Certified filings (log scale)
Shire Human Genetic Therapies H-1B worksite states
StateFilingsMedian base
MA211$110k
PA2$57k

What has Shire Human Genetic Therapies filed recently?

The 50 most recent of 213 certified LCAs: job title, worksite, prevailing-wage level and the offered base salary.

Shire Human Genetic Therapies recent certified H-1B LCA filings
FYJob titleBase salary
2026Senior Process Validation Engineer I$113,075
2026Sr. Validation Engineer$133,120
2026Project Management, Principal Analyst$140,000
2026Senior Validation Engineer I$112,000
2026Automation Hardware Engineer$196,950
2026Validation Manager$169,914
2025Quality Manager - QA Operations$147,733
2025Automation Engineer$93,000
2025Senior Process Validation Engineer I$109,781
2025Director, Head of Manufacturing Science Downstream$225,000
2025Senior Manager, Process Engineering$160,775
2025Senior Validation Engineer$128,426
2024QC Analyst II$85,000
2024Project Portfolio Specialist$126,561
2024Validation Engineer - Process Validation, Professional II$101,706
2024Senior Engineer II$138,820
2024Cmc Submission Lead$97,000
2024Team Lead, Device Regulatory Affairs, Pdt Bu$210,251
2024Regulatory Lead$152,193
2024Senior Validation Engineer II$154,166
2024Regulatory Lead$152,193
2024Director, Quality Risk Management$197,450
2024Product Quality Lead$195,000
2024Digital Analyst$130,000
2024Digital Analyst$130,000
2024Quality Disposition Manager$139,252
2024Sr. Validation Engineer$130,000
2024Validation Engineer II$98,000
2023Associate Director, Cmc Regulatory Submissions$179,106
2023Application Engineer$149,241
2023Quality Control Scientist I$115,000
2023Validation Manager$154,295
2023Team Lead, Global Reg Affairs Device, Pdt$204,127
2022Senior Staff Engineer$142,000
2022Senior Validation Engineer$115,000
2022Senior Research Associate$85,000
2022Process Engineering Manager$135,000
2022Associate Director$172,474
2022Portfolio Specialist$118,000
2022Sr. Manager, Regulatory Strategy Cmc$169,496
2022Process Validation Engineer II$92,650
2022Senior Engineer II - Material Qualifications$125,000
2021Senior QC Analyst$113,782
2021QC Scientist$117,000
2021Senior Process Validation Engineer II$145,000
2021Senior Regulatory Affairs Associate$96,200
2021Regulatory Project Manager$109,350
2021Associate Director, Analytics & Data Quality Gma$180,000
2021Senior Downstream Engineer I$105,183
2021Plant Engineer II$82,760

See all 213 filings →

Common questions about Shire Human Genetic Therapies's H-1B filings

How much does Shire Human Genetic Therapies pay H-1B workers?
Shire Human Genetic Therapies's median certified H-1B base salary is $128k (FY2025), from 6 filings. See the full salary distribution and percentiles above.
How many H-1B workers does Shire Human Genetic Therapies sponsor?
Shire Human Genetic Therapies has 213 certified H-1B Labor Condition Applications on record (FY2016–FY2026).
What jobs does Shire Human Genetic Therapies sponsor for H-1B?
Shire Human Genetic Therapies's most-sponsored H-1B roles include Downstream Development Engineer II, QC Analyst II, Senior Validation Engineer, Development Specialist II.
Where does Shire Human Genetic Therapies hire H-1B workers?
Shire Human Genetic Therapies's top H-1B worksite states are MA, PA.
Does a certified LCA mean an H-1B visa was approved?
No. A Labor Condition Application (LCA) is the Department of Labor attestation an employer must have certified before filing an H-1B petition with USCIS. It records the job, worksite and offered wage, but not whether the petition was filed, selected in the lottery, or approved. Filing counts measure intent to sponsor, not headcount.
What salary do these figures show?
The base annual wage offered on the certified LCA, converted to a yearly amount. Bonus, equity, overtime and benefits are not included, so total compensation is typically higher. Figures are medians and percentiles over certified filings; wages above $5,000,000 a year are excluded as data-entry errors.
What do prevailing-wage levels I–IV mean?
The Department of Labor assigns each LCA an OES wage level from I (entry) to IV (fully competent) for the occupation and area. Under the FY2027 wage-weighted H-1B lottery rule, a higher level earns more selection entries, so an employer's level mix is a proxy for how senior its sponsored roles are.

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Source: U.S. Department of Labor, Office of Foreign Labor Certification — certified LCA disclosure data through June 2026 (FY2016–FY2026). An LCA is not an approved visa; pay figures are base salary and exclude bonus and equity. Methodology →